Clinical Management: Oncology Flashcards

Which laboratory abnormality is especially common with lorlatinib and requires routine monitoring?

Answer: Hyperlipidemia (elevated cholesterol and triglycerides)

Lorlatinib causes hypercholesterolemia and hypertriglyceridemia in most patients, often requiring lipid-lowering therapy.

Venetoclax for CLL is started with a 5-week dose ramp-up primarily to reduce the risk of which complication?

Answer: Tumor lysis syndrome

Venetoclax rapidly kills CLL cells, so gradual titration from 20 mg to 400 mg with hydration and monitoring mitigates TLS.

Which adverse effect is characteristically associated with dasatinib?

Answer: Pleural effusion

Dasatinib commonly causes fluid retention including pleural effusions, sometimes requiring dose interruption or reduction.

Which counseling point is correct for nilotinib?

Answer: Take on an empty stomach, avoiding food 2 hours before and 1 hour after each dose

Food markedly increases nilotinib exposure and QT prolongation risk, so it must be taken on an empty stomach.

Which CDK4/6 inhibitor is most associated with diarrhea as a dose-limiting toxicity?

Answer: Abemaciclib

Abemaciclib causes frequent early-onset diarrhea, and patients should start loperamide at the first loose stool.

Sotorasib is indicated for NSCLC harboring which specific mutation?

Answer: KRAS G12C

Sotorasib covalently and irreversibly inhibits the KRAS G12C mutant protein.

Enzalutamide should be used with caution in patients with which history?

Answer: Seizure disorder

Enzalutamide lowers the seizure threshold through GABA-A inhibition and is associated with seizures.