General MCQ Flashcards

A 6-year-old presents with honey-colored crusts around the nose and mouth. What is the most likely diagnosis?

Answer: Impetigo

Honey-colored crusting on the face is the classic presentation of non-bullous impetigo, usually caused by Staphylococcus aureus or Streptococcus pyogenes.

Which HLA type is most strongly associated with dermatitis herpetiformis?

Answer: HLA-DQ2

Dermatitis herpetiformis, the cutaneous manifestation of celiac disease, is strongly linked to HLA-DQ2 (and DQ8).

A pearly papule with rolled borders and telangiectasias on the nose is most consistent with which tumor?

Answer: Basal cell carcinoma

A pearly, translucent papule with rolled borders and arborizing telangiectasias is the hallmark of nodular basal cell carcinoma.

Nikolsky sign, where the epidermis shears with lateral pressure, is characteristically positive in which condition?

Answer: Pemphigus vulgaris

Pemphigus vulgaris involves intraepidermal acantholysis, producing a positive Nikolsky sign, unlike the subepidermal bullous pemphigoid.

Which medication is first-line oral therapy for severe nodulocystic acne?

Answer: Isotretinoin

Isotretinoin is the most effective agent for severe recalcitrant nodulocystic acne, though it requires pregnancy prevention monitoring.

The Auspitz sign (pinpoint bleeding after scale removal) is associated with which disease?

Answer: Psoriasis

Removing the silvery scale of a psoriatic plaque exposes dilated dermal capillaries, producing pinpoint bleeding known as the Auspitz sign.

A patient develops a target-shaped lesion with three concentric zones after a herpes simplex outbreak. What is the diagnosis?

Answer: Erythema multiforme

Classic targetoid lesions with three zones following HSV infection are diagnostic of erythema multiforme.